Cryptolepine derivatives
Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebApr 2, 2024 · DOI: 10.3390/molecules28073162 Corpus ID: 257943404; One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of γ-Hydroxybutyrolactams @article{Abaev2024OnePotSO, title={One-Pot Synthesis of Polynuclear Indole Derivatives by Friedel–Crafts Alkylation of $\gamma$-Hydroxybutyrolactams}, author={Vladimir T …
Cryptolepine derivatives
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WebNov 18, 2011 · Materials and Methods Cryptolepine derivatives. Cryptolepine, its 11-chloro- and 2,7-dibromo- analogues, and quindoline were synthesised as previously reported. [] The 2-fluorocryptolepine and 2-methoxycryptolepine derivatives were prepared as described by Ablordeppey et al. [] Cryptolepine-11-one was derived from … WebFeb 26, 2024 · In this study, neocryptolepine and its derivatives (1-49) were designed and synthesized from economical and readily available starting materials. Their structures were confirmed by proton nuclear magnetic resonance, carbon nuclear magnetic resonance, and mass spectrometry.
WebOct 6, 2024 · Abstract To ensure the production of food crops, a series of cryptolepine derivatives were synthesised, after which their antibacterial activities and mechanism of … WebApr 3, 2024 · Derivatives of 1 Full size image 5 Anticholinesterase and β-Amyloid Effects Cryptolepine ( 1) and 2-bromocryptolepine have been shown to be potent ( IC50 < 100 n M ), non-competitive inhibitors of both acetyl- and butyryl-cholinesterases (BACE) [ 21 ].
WebFeb 8, 2024 · A series of quinoline derivatives were designed and synthesized by the structural simplification of cryptolepine and evaluated for their fungicidal activity against six phytopathogenic fungi. Most of these compounds exhibited remarkable activities against Botrytis cinereain vitro. WebThe strong binding interactions of these derivatives show that they can be used as potent TOP2A inhibitors and act as more effective anticancer agents than cryptolepine itself. …
WebFeb 16, 2016 · Cryptolepis / chemistry Drug Synergism Drug Therapy, Combination Indole Alkaloids / pharmacology Indole Alkaloids / therapeutic use Malaria / drug therapy* Male Mice Mice, Inbred ICR Plasmodium berghei / drug effects Plasmodium berghei / physiology Quinolines / pharmacology Quinolines / therapeutic use Rats Rats, Sprague-Dawley
WebMar 2, 2024 · Based on the structural characteristics of the cryptolepine alkaloid, a series of new quindoline derivatives bearing various substituents were prepared and evaluated … echo reporting incWebMar 3, 2005 · A series of analogues of cryptolepine (1) have been synthesized and evaluated for their in vitro antiplasmodial and cytotoxic properties. The IC50 values of several compounds (11a, 11k−m, 11o, 13) against Plasmodium falciparum (strain K1) were <0.1 μM, 5−10-fold lower than that of 1 but their cytotoxicities were only 2−4 times greater … compton twth express incWebSep 19, 2012 · Abstract In order to improve the selectivity of 5-N-methyl quindoline (cryptolepine) derivatives as telomeric quadruplex binding ligands versus duplex DNA, a series of peptidyl-benzofuroquinoline (P-BFQ) conjugates (2a-2n) … echo resale store evergreen cocompton \u0026 wendler pcWebJun 9, 2024 · A combinatorial library of 31114 derivatives of cryptolepine was formed and the library was virtually screened by molecular docking to predict the molecular interactions between cryptolepine derivatives and TOP2A taking cryptolepine as standard. The overall screening and docking approach explored all the binding poses of cryptolepine … compton tortoiseshellWebMar 2, 2024 · Abstract Based on the structural characteristics of the cryptolepine alkaloid, a series of new quindoline derivatives bearing various substituents were prepared and evaluated for their fungicidal and antibacterial activities. echo respirometer service manualWebJun 9, 2024 · A combinatorial library of 31114 derivatives of cryptolepine was formed and the library was virtually screened by molecular docking to predict the molecular … echo research \\u0026 practice