WebMar 9, 2024 · IRF-1 regulates Rab27a transcription and extracellular vesicles secretion, leading to oxidized phospholipid activation of neutrophils and subsequent hepatic ischemia reperfusion injury. Low IRF1 expression is associated with lymphoma. WebSep 29, 2024 · Innate lymphoid cells (ILC) are involved with different immune responses. Here the authors show that Interferon regulatory factor 1 (IRF1) is important for intestinal ILC3 accumulation during ...
IRF1 Promotes the Innate Immune Response to Viral …
WebThis maturation process was perturbed by specific inactivation of either NF-κB or IFN regulatory factor 1 (IRF1) in cDC1s, resulting in impaired expression of IFN-γ–responsive genes and consequently a failure to efficiently recruit and activate antitumoral CD8 + T cells. WebJun 17, 2024 · Interferon regulatory factor 1 (IRF1) is a critical transcription factor for the development of both the innate and adaptive immune responses against infections. However, the molecular mechanism through which PARP1 mediates the effects has not been clearly demonstrated. Jurkat cells were exposed to dexamethasone (Dex) or PARP1 … the point of fast food ads
Interferon regulatory factor 1 (IRF1) and anti-pathogen …
WebMay 22, 2024 · To verify that IRF1 directly promoted CIITA expression, ChIP assays were performed. The empty vector or IRF1-containing plasmid and CIITA promoter were co-transfected into 293T cells, and the result showed that IRF1 could bind to the CIITA promoter directly . The promoter sequence of grass carp CIITA gene containing the … WebJul 9, 2015 · Irf1 constitutively expressed in the developing thymus plays an essential role in positive and negative selection of the CD8 + T cell repertoire [57,61]. MHC class I-restricted CD8 + T lymphocytes are directed against peptides derived from cytosolic proteins degraded by the proteasome that are translocated across the ER membrane by the TAP1 ... WebJun 30, 2016 · We identified IRF1 as the STAT3-inducible proapoptotic factor mediating chemosensitization. Notably, our data show that pretreatment IRF1 expression correlates with the response to radio/chemotherapy in cervical cancer patients in vivo. Materials and Methods Immunohistochemical analysis side windshield replacement